The 1980–81 UC Irvine Anteaters men's basketball team represented the University of California, Irvine during the 1980–81 NCAA Division I men's basketball season. The Anteaters were led by first year head coach Bill Mulligan and played their home games at the Crawford Hall. They were members of the Pacific Coast Athletic Association. They finished the season 17–10 and 9–5 in PCAA play.