2-Phospho-L-lactate guanylyltransferase (EC 2.7.7.68, CofC, MJ0887) is an enzyme with systematic name GTP:2-phospho-L-lactate guanylyltransferase. This enzyme catalyses the following chemical reaction (2S)-2-phospholactate + GTP (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate This enzyme is involved in the biosynthesis of coenzyme F420.
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