The 2000 season was the Arizona Cardinals' 81st season in the National Football League (NFL), their 102nd overall and their 13th in Arizona. The Cardinals ranked 24th in the NFL in total offense and 30th in total defense. The Cardinals ranked last in the NFC in Takeaways/Giveaways with a rating of −24. The Cardinals surrendered 443 points in 2000, the second-worst in the NFL that season, and second-worst in franchise history. Arizona's minus-233 point differential is the worst in team history.