The St. Louis Cardinals 2001 season was the team's 120th season in St. Louis, Missouri and the 110th season in the National League. The Cardinals went 93-69 during the season and finished tied for first in the National League Central division with the Houston Astros. Because the best two teams in the National League were both from the Central Division and both the Cardinals and Astros finished five games ahead of the third-place Chicago Cubs, the Astros were awarded the NL Central champion and the number one seed in the playoffs due to winning the season series 9–7, and the Cardinals were seeded as the wild-card.