The 2005 Coca-Cola 600, the 46th running of the race, was a NASCAR Nextel Cup Series race held on May 29, 2005, at Lowe's Motor Speedway in Charlotte, North Carolina. The race was the twelfth of the 2005 NASCAR Nextel Cup Series season. The pole position was won by Penske Racing's Ryan Newman, while the race was won by Jimmie Johnson of Hendrick Motorsports in a fantastic finish against Bobby Labonte. The race featured the most caution flags in Cup history at 22 cautions for 103 laps, as well as the most lap leaders (21) in track history.