The 2010 Houston Astros season was the 49th season in the history of the franchise. The team, managed by first-year manager Brad Mills, began their 11th season at Minute Maid Park and 46th as the Astros on April 5. After finishing 74–88 the year before in 5th place, the Astros finished 76–86 in 4th place in 2010. This was the best before the Astros moved to American League in 2013.