The men's 4x400 metres relay competition at the 2010 IAAF World Indoor Championships was held at the ASPIRE Dome on 13 and 14 March. In the first heat the United States and Jamaica took the top two spots as expected, shortly followed by the Dominican Republic in a national record time of 3:06.30. In the second heat, a clash between and Marcin Marciniszyn resulted in a baton drop by Russia, which eventually cost them a place in the final. Belgium won heat two but the initial second placers Botswana (which ran an African record of 3:09.60) were later disqualified for a baton exchange outside of the legal zone. The Bahamas benefited from the disqualification and the Dominican Republic and Great Britain entered the final as the fastest losers.