The 2012–13 Santos Laguna season was the 66th professional season of Mexico's top-flight football league. The season is split into two tournaments—the Torneo Apertura and the Torneo Clausura—each with identical formats and each contested by the same eighteen teams. Santos Laguna began their season on July 21, 2012 against San Luis, Santos Laguna played most their homes games on Saturdays at 7:00pm local time. Santos Laguna did not qualify to the final phase in the Apertura tournament and was eliminated in the semi-finals of the final phase by Cruz Azul in the Clausura tournament. Santos Laguna lost the 2012–13 CONCACAF Champions League final to Monterrey 4–2 on aggregate.