The 2015–16 Louisville Cardinals women's basketball team will represent the University of Louisville during the 2015–16 NCAA Division I women's basketball season. The Cardinals, led by ninth-year head coach Jeff Walz, play their home games at the KFC Yum! Center and were in their second year in the Atlantic Coast Conference. They finished the season 26–8, 15–1 in ACC play to finish in second place. They advanced to the semifinals of the ACC women's tournament where they lost to Syracuse. They received at-large bid of the NCAA women's tournament where they defeated Central Arkansas in the first round before losing to DePaul in the second round.