The 2015–16 Southern Miss Golden Eagles men's basketball team represented the University of Southern Mississippi during the 2015–16 NCAA Division I men's basketball season. The Golden Eagles, led by second year head coach Doc Sadler, played their home games at Reed Green Coliseum and were members of Conference USA. They finished the season 8–21, 5–13 in C-USA play to finish in a tie for 12th place.