The 2015 Tennessee State Tigers football team represented Tennessee State University as a member of the Ohio Valley Conference (OVC) in the 2015 NCAA Division I FCS football season. Led by sixth-year head coach Rod Reed, the Tigers compiled an overall record of 4–6 with a mark of 1–6 in conference play, placing eighth in the OVC. Tennessee State played home games in Nashville, Tennessee at Nissan Stadium and Hale Stadium.