The 2016–17 Prairie View A&M Panthers basketball team represented Prairie View A&M University during the 2016–17 NCAA Division I men's basketball season. The Panthers, led by first-year head coach Byron Smith, played their home games at the William Nicks Building in Prairie View, Texas as members of the Southwestern Athletic Conference. They finished the season 13–20, 10–8 in SWAC play to finish in a four-way tie for third place. As the No. 4 seed in the SWAC tournament, they lost to Grambling State in the quarterfinals.