The 2016 Wyoming Cowboys football team represented the University of Wyoming during the 2016 NCAA Division I FBS football season. The Cowboys were coached by third year head coach Craig Bohl and played their home games at War Memorial Stadium. They participated in the Mountain Division of the Mountain West Conference. They finished the season 8–6, 6–2 in Mountain West play to finish in a three-way tie for the Mountain Division championship. After tiebreakers, they represented the Mountain Division in, and hosted, the Mountain West Championship Game where they lost to San Diego State. They were invited to the Poinsettia Bowl where they lost to BYU.