The 2017–18 Oklahoma State Cowgirls basketball team represented Oklahoma State University in the 2017–18 NCAA Division I women's basketball season. The Cowgirls, led by seventh year head coach Jim Littell, played their home games at Gallagher-Iba Arena and were members of the Big 12 Conference. They finished the season 21–11, 11–7 in Big 12 play to finish in a tie for third place. They lost in the quarterfinals of the Big 12 women's tournament to West Virginia. They received an at-large bid of the NCAA women's basketball tournament where they defeated Syracuse in the first round before losing to Mississippi State in the second round.