The 2018–19 Cal Poly Mustangs men's basketball team represented California Polytechnic State University in the 2018–19 NCAA Division I men's basketball season. The Mustangs were led by tenth-year head coach Joe Callero and played their home games at the Mott Athletics Center. Cal Poly was a member of the Big West Conference, and participated in their 23rd consecutive season in that league. They finished the season 6–23 overall, 2–14 in Big West play to finish in ninth place. They failed to qualify for the Big West Conference tournament. On March 6, 2019, it was announced that head coach Joe Callero would not be retained after his 10th season. He compiled a record of 126–184 while at Cal Poly.