The 2018–19 Ole Miss Rebels women's basketball team represented the University of Mississippi during the 2018–19 NCAA Division I women's basketball season. The Rebels, led by first-year head coach Yolett McPhee-McCuin, played their home games at the Pavilion at Ole Miss and competed as members of the Southeastern Conference (SEC). They finished the season 9–22, 3–13 in SEC play to finish in a tie for twelfth place. They lost in the first round of the SEC women's tournament to Florida.