The 2018 Nicholls State Colonels football team represented Nicholls State University as a member of the Southland Conference during the 2018 NCAA Division I FCS football season. Led by fourth-year head coach Tim Rebowe, the Colonels compiled an overall record of 9–4 with a mark of 7–2 in conference play, sharing the Southland title with Incarnate Word. Nicholls State received the Southland's automatic bid to the NCAA Division I Football Championship, beating San Diego in the first round before losing to Eastern Washington in the second round. The team played home games at John L. Guidry Stadium in Thibodaux, Louisiana.