The 2018 Southeast Missouri State Redhawks football team represented Southeast Missouri State University as a member of the Ohio Valley Conference (OVC) during the 2018 NCAA Division I FCS football season. Led by fifth-year head coach Tom Matukewicz, the Redhawks compiled an overall record of 9–4 with a mark of 6–2 in conference play, placing second in the OVC. Southeast Missouri State received an at-large bid to the NCAA Division I Football Championship playoffs, where they defeated Stony Brook in the first round before losing to Weber State in the second round. The team played home games at Houck Stadium in Cape Girardeau, Missouri.