The 2019–20 Iowa State Cyclones women's basketball team represented Iowa State University during the 2019–20 NCAA Division I women's basketball season. The Cyclones were coached by Bill Fennelly, who was in his 25th season at Iowa State. They played their home games at Hilton Coliseum in Ames, Iowa as members of the Big 12 Conference. They finished the season 18–11, 10–8 in Big 12 play to finish in a tie for fourth place. The Big 12 Tournament, NCAA women's basketball tournament and WNIT were all cancelled before they began due to the COVID-19 pandemic.