The 2019 season was the 98th in the Cruzeiro Esporte Clube's existence. Along with the Campeonato Brasileiro Série A, the club also competed in the Campeonato Mineiro, the Copa do Brasil and the Copa Libertadores. On 30 July, Cruzeiro were knocked out of Copa Libertadores on penalties to River Plate in the round of 16 stage, after a 0–0 tie on aggregate. On 4 September, the club were eliminated by Internacional in the Copa do Brasil semi-finals, losing 4–0 on aggregate.