The 2020–21 season was the 111th season in the existence of Cádiz CF and the club's first season back in the top flight of Spanish football since 2006. In addition to the domestic league, Cádiz CF participated in this season's edition of the Copa del Rey. The season covered the period from 21 July 2020 to 30 June 2021, with the late start to the season due to the COVID-19 pandemic in Spain.