The 2020–21 Duke Blue Devils women's basketball team represented Duke University during the 2020–21 NCAA Division I women's basketball season. The Blue Devils were led by first year head coach Kara Lawson and played their home games at Cameron Indoor Stadium in Durham, North Carolina as members of the Atlantic Coast Conference. During the off-season, Duke announced that head coach Joanne McCallie had retired after thirteen years as head coach. On July 11, 2020, Kara Lawson was announced as the new head coach.