The 2020–21 EHF Champions League knockout stage began on 31 March with the playoffs and ended on 13 June 2021 with the final at the Lanxess Arena in Cologne, Germany, to decide the winners of the 2020–21 EHF Champions League. On 10 February 2021, after a decision by the EHF Executive Committee, it was announced that all 16 teams advance from the group stage.