The 2020–21 Louisville Cardinals women's basketball team represented the University of Louisville during the 2020–21 NCAA Division I women's basketball season. The Cardinals, were led by 14th-year head coach Jeff Walz, and played their home games at the KFC Yum! Center in their seventh year in the Atlantic Coast Conference. On January 18th, 2021, following a 12-0 start, the Cardinals were ranked number 1 in the AP Poll for the first time in program history, garnering 20 of 29 first place votes.