The Northeastern Huskies represented Northeastern University in the Women's Hockey East Association during the 2020–21 NCAA Division I women's ice hockey season. In addition to capturing the regular season title, the Huskies defeated the Providence Friars by a 6–2 mark to win the Hockey East postseason tournament. Qualifying for the 2021 NCAA National Collegiate Women's Ice Hockey Tournament, the program ranked as the #1 seed. The Huskies lost to Wisconsin 1–2 in overtime in the national championship game.