The 2020–21 Notre Dame Fighting Irish women's basketball team represented the University of Notre Dame during the 2020–21 NCAA Division I women's basketball season. The Fighting Irish were led by first year head coach Niele Ivey and played their home games at Purcell Pavilion as members of the Atlantic Coast Conference. The Fighting Irish finished the season 10–10 and 8–7 in ACC play to finish in sixth place. In the ACC tournament, they lost to Clemson in the Second Round. They were not invited to the NCAA tournament or the WNIT.