The 2020–21 season was the 98th season in the existence of Vitória S.C. and the club's 14th consecutive season in the top-flight of Portuguese football. In addition to the domestic league, Vitória de Guimarães participated in this season's editions of the Taça de Portugal and the Taça da Liga. The season covers the period from 26 July 2020 to 30 June 2021.