The 2021–22 season was Associazione Calcio Monza's 40th season—and second in a row—in the Serie B, the second level of Italian football. The club ended the Serie B campaign in fourth place, and participated in the promotion play-offs. After defeating Pisa after extra time in the final, Monza were promoted to the Serie A for the first time in their history. They also participated in the Coppa Italia, the Italian domestic cup, and were eliminated in the round of 64.