The 2021–22 American Eagles men's basketball team represented American University in the 2021–22 NCAA Division I men's basketball season. The Eagles, led by eighth-year head coach Mike Brennan, played their home games at Bender Arena in Washington, D.C. as members of the Patriot League. They finished the season 10–22, 5–13 in Patriot League play to finish in a tie for last place. As the No. 10 seed in the Patriot League tournament, they defeated Holy Cross in the first round before losing to Navy in the quarterfinals.