The 2021–22 CSA One-Day Cup was a List A cricket competition that took place in South Africa in March and April 2022. It was the first edition of the tournament in the post-franchise era, and the first edition to return to a two-division league format. Domestic cricketing reforms were introduced in 2020 that discontinued the six franchise team format and announced a return to the more traditional provincial based system. Fifteen teams, split over the two divisions, competed in the one-day tournament.