The 2021–22 Clemson Tigers women's basketball team represented Clemson University during the 2021–22 college basketball season. The Tigers were led by fourth year head coach Amanda Butler. The Tigers, members of the Atlantic Coast Conference, played their home games at Littlejohn Coliseum. During the offseason, assistant coach Shimmy Gray-Miller left Clemson to become assistant coach at Minnesota. The Tigers hired Priscilla Edwards as her replacement.