In the 2021–22 season, Espérance Sportive de Tunis competed in the Ligue 1 for the 67th season, as well as the Tunisian Cup. It was their 67th consecutive season in the top flight of Tunisian football. They competed in Ligue 1, the Champions League, the Tunisian Cup, 2019–20 Tunisian Super Cup and the 2020–21 Tunisian Super Cup. On the continental front, Espérance de Tunis left the Champions League from the quarter-finals after a surprise loss to ES Sétif with a score of 1–0 on aggregate.