The 2021–22 season was the 35th season for FC Barcelona Femení. In addition to the domestic league, Barcelona played in that season's editions of the Copa de la Reina and UEFA Women's Champions League. Barcelona were coming off a successful 2020–21 campaign by being the first Spanish women's club to win the continental treble after winning the league, UEFA Women's Champions League, and Copa de la Reina. Grant Wahl has called the side one of the best women's club teams in history.