The 2021–22 Iowa State Cyclones men's basketball team represents Iowa State University during the 2021–22 NCAA Division I men's basketball season. The Cyclones are coached by T. J. Otzelberger, who is in his first season as head coach, and ninth season at Iowa State. They play their home games at Hilton Coliseum in Ames, Iowa as members of the Big 12 Conference.