The 2021–22 Lietuvos krepšinio lyga, also called Betsafe-LKL for sponsorship reasons, was the 29th season of the top-tier level professional basketball league of Lithuania, the Lietuvos krepšinio lyga (LKL). Žalgiris was defending champions. For the first time since league's inception, Žalgiris failed to reach finals, after losing semifinal series to Lietkabelis 3–1 Rytas after 12 years break won Betsafe–LKL championship and achieved their 6th title overall.