The 2021–22 La Salle Explorers men's basketball team represented La Salle University during the 2021–22 NCAA Division I men's basketball season. The Explorers, led by fourth-year head coach Ashley Howard, played their home games at Tom Gola Arena in Philadelphia, Pennsylvania as members of the Atlantic 10 Conference. They finished the season 11–19, 5–13 in A-10 play to finish in a tie for 12th place. As the No. 12 seed in the A-10 tournament, they defeated Saint Joseph's in the first round before losing to Saint Louis in the second round.