The 2021–22 Melbourne Renegades Women's season was the seventh in the team's history. Coached by Simon Helmot and captained by Sophie Molineux, the Renegades were not scheduled to play any WBBL|07 games in their home state of Victoria due to ongoing border restrictions related to the COVID-19 pandemic. They nevertheless finished the regular season in second position—their best performance across the WBBL's first seven editions—catapulted by a standout campaign from Indian marquee Harmanpreet Kaur, who was named Player of the Tournament.