The 2021–22 Moldovan National Division (Romanian: Divizia Națională) was the 31st season of top-tier football in Moldova. The season started on 1 July 2021 and ended on 14 May 2022. Sheriff Tiraspol were the defending champions. The winners of the league this season earned a spot in the first qualifying round of the 2022–23 UEFA Champions League, and the second, third and fourth placed clubs earned a place in the first qualifying round of the 2022–23 UEFA Europa Conference League.