The 2021–22 NIFL Championship (known as the Lough 41 Championship for sponsorship reasons) was the fifth season of the NIFL Championship since gaining senior status. It is the second-tier of the Northern Ireland Football League - the national football league in Northern Ireland. The season began on 7 August 2021 and concluded on 30 April 2022. The Championship returned after a one-year hiatus, following the cancellation of the 2020–21 season due to the COVID-19 pandemic in Northern Ireland.