The 2021–22 Nigeria Professional Football League was the 51st season of Nigeria's top-flight association football league and the 32nd since attaining professionalism. The season started on 17 December 2021 and was concluded on 17 July 2022. This season saw Shooting Stars returning to the top-flight after a four-year hiatus, likewise Niger Tornadoes who won the play-offs. They were also joined by Remo Stars and Gombe United after securing promotion from the second division. Akwa United were the defending champions.