The 2021–22 North Texas Mean Green men's basketball team represented the University of North Texas during the 2021–22 NCAA Division I men's basketball season. The team was led by fifth-year head coach Grant McCasland, and played their home games at UNT Coliseum in Denton, Texas as a member of the West division of Conference USA. They finished the season 25-7, 16-2 in C-USA Play to finish as regular season champions. They defeated Rice in the quarterfinals of the C-USA tournament before losing in the semifinals to Louisiana Tech. As a No. 1 seed who didn’t win their conference tournament, they received an automatic bid to the National Invitation Tournament where they defeated Texas State in the first round before losing in the second round to Virginia.