The 2021–22 Oklahoma State Cowboys basketball team represented Oklahoma State University during the 2021–22 NCAA Division I men's basketball season. The team was led by fifth-year head coach Mike Boynton, and played their home games at Gallagher-Iba Arena in Stillwater, Oklahoma as a member of the Big 12 Conference. On November 3, 2021, the NCAA ruled Oklahoma State ineligible for postseason play for the season due to player receiving improper benefits.