The 2021–22 Pac-12 Conference women's basketball season began with practices in October followed by the 2021–22 NCAA Division I women's basketball season which started on November 9. Conference play began on December 31. This is the tenth season under the Pac–12 Conference name and the 36th since the conference first sponsored women's sports, including basketball, in the 1986–87 school year. The Pac-12 tournament took place from March 2–6 at the Michelob Ultra Arena in Paradise, Nevada.