The 2021–22 San Francisco Dons men's basketball team represented the University of San Francisco during the 2021–22 NCAA Division I men's basketball season. The Dons were led by third-year head coach Todd Golden, and played their home games at the War Memorial Gymnasium at the Sobrato Center as members of the West Coast Conference. The day after the tournament loss, March 18, 2022, head coach Todd Golden accepted the head coach role at Florida. Chris Gerlufsen was subsequently named the next head coach.