The 2021–22 South Alabama Jaguars men's basketball team represented the University of South Alabama in the 2021–22 NCAA Division I men's basketball season. The Jaguars, led by fourth-year head coach Richie Riley, play their home games at the Mitchell Center in Mobile, Alabama as members in the Sun Belt Conference. The Jaguars are set to play in the inaugural 2022 The Basketball Classic postseason tournament.