The 2021–22 South Dakota State Jackrabbits men's basketball team represented South Dakota State University in the 2021–22 NCAA Division I men's basketball season. The Jackrabbits, led by third-year head coach Eric Henderson, played their home games at Frost Arena in Brookings, South Dakota, as members of the Summit League. They finished the season 30–5, 18–0 in Summit League Play to finish as regular season champions. As the No. 1 seed, they defeated Omaha, South Dakota, and North Dakota State to win the Summit League tournament. They received the conference’s automatic bid to the NCAA tournament as the No. 13 seed in the Midwest Region, where they lost in the first round to Providence.