The 2021–22 season is Tranmere Rovers's 138th year in their history and second consecutive season in League Two. Along with the league, the club are also competing in the FA Cup, the EFL Cup and the 2021–22 EFL Trophy. The season covers the period from 1 July 2021 to 30 June 2022. During pre-season, Micky Mellon returned to the club as he was announced as the new manager.