The 2021–22 UAB Blazers men's basketball team represented the University of Alabama at Birmingham during the 2021–22 NCAA Division I men's basketball season. The team was led by second-year head coach Andy Kennedy, and played their home games at the Bartow Arena in Birmingham, Alabama as a member of Conference USA. They finished the season 27–8, 14–4 in C-USA play to finish second in the West Division. As the No. 2 seed out of the West Division, they defeated Florida Atlantic, Middle Tennessee, and Louisiana Tech to win the C-USA tournament. They received the conference’s automatic bid to the NCAA tournament as the No. 12 seed in the South Region, where they lost in the first round to Houston.