The 2021–22 UEFA Women's Champions League group stage, which is first ever group stage of the competition, began on 5 October 2021 and ended on 16 December 2021. A total of 16 teams will compete in the group stage to decide the 8 places in the knockout phase of the 2021–22 UEFA Women's Champions League. Køge, 1899 Hoffenheim and Real Madrid were playing in Europe for the first time this season. Benfica, Juventus, Zhytlobud-1 Kharkiv and Servette Chênois made their debut appearance in the last 16 under any format. Benfica were the first team from Portugal to in the last 16.