The 2021 season was Lightning's second season, in which they competed in the 50 over Rachael Heyhoe Flint Trophy and the new Twenty20 competition, the Charlotte Edwards Cup. The side finished fourth in the Rachael Heyhoe Flint Trophy, with 3 wins from their 7 matches. In the Charlotte Edwards Cup, the side finished bottom of Group A, losing all 6 of their matches.